With correct treatment, women with diminished ovarian reserve can still have an excellent chance of pregnancy with the use of their own eggs.
Dr. Gleicher (a physician at Center for Human Reproduction in New York, NY) explains early and premature menopause, how it is linked to diminished ovarian reserve and the use of DHEA supplementation for improving ovarian reserve.
June 4, 2012 (New York, NY) – Center for Human Reproduction (CHR), a New York fertility center with special expertise in treating women with “older-behaving” ovaries, reported significantly improved ongoing clinical pregnancy rates for 2011 at practically all age groups. The improvement was, however, most pronounced in women above age 44 years, where the rate doubled from the previous year.
Pregnancy rates are calculated by dividing the number of clinical pregnancies by that of embryo transfers. While most age groups saw increases in IVF pregnancy rates, the most dramatic improvement in pregnancy rates were observed in women at ages 44-49, where pregnancy rates increased to 10.3%.
“This pregnancy rate for women 44-49 is almost unbelievable, considering that patients at these ages, at most other IVF centers in the world, are no longer even given the chance of pregnancy with use of their own eggs and are usually advised to use donor eggs, “ notes David H. Barad, MD, Director of Clinical ART at CHR. “These results reflect our center’s fight for every egg and every embryo in older women seeking fertility treatment, based on the accumulated results of very active, decade-long research in how to successfully treat ‘older’ ovaries.”
In concentrating most of the center’s research on “older-behaving” ovaries, CHR developed many major clinical breakthroughs, like DHEA (androgen) supplementation, which has since become standard treatment around the world. CHR investigators also recently confirmed the importance of androgens (male hormones) for follicle and egg maturation.
“What makes these pregnancy rates even more remarkable are the patients in whom we achieved them,” adds Norbert Gleicher, MD, Medical Director and Chief Scientist of CHR. As a result of premature ovarian aging (POA), even younger patients of CHR, in most cases, have ovaries that behave like those of much older women.” Dr. Gleicher continues: “The majority of our patients have previously failed IVF cycles elsewhere, and have been turned away by other fertility centers as ‘hopeless’ unless willing to use donor eggs. CHR was their fertility center of last resort. Achieving pregnancies at these rates in these women is practically unprecedented.”
About Center for Human Reproduction
The Center for Human Reproduction (CHR, http://www.centerforhumanreprod.com), is one of the world’s leading fertility centers, with, currently, over half of the center’s patients coming from outside the larger New York tristate area, approximately a quarter from overseas and Canada. CHR has a worldwide reputation as the “fertility center of last resort,” specializing in treatment of infertility in women with diminished ovarian reserve due to advanced age or, in younger women, due to premature ovarian aging (POA).
Dr. Gleicher and Dr. Barad are available for further comments.
March 1, 2012 (New York, NY) – Center for Human Reproduction (CHR), a leading New York fertility center specializing in pregnancy in older women, has issued a fertility tip sheet for women trying to get pregnant after age 40. With a growing number of women interested in pregnancy over 40, timely evaluation and diagnosis of infertility are becoming ever more important. However, they remain elusive for many patients.
“It’s important to recognize the urgency of aggressive fertility treatment when you are above age 40,” says Dr. Gleicher, Medical Director of CHR, which released the tip sheet. As women get older, their ovarian reserve (a measure of ovaries’ ability to produce good-quality eggs) declines. Because this process of ovarian aging speeds up significantly after age 40, timely diagnosis of infertility becomes crucial especially after age 40. Every fertility treatment loses efficacy rapidly with declining ovarian reserve.
As a “fertility center of last resort” for patients with diminished ovarian reserve, CHR sees a large number of women over 40 with premature ovarian aging. Dr. Gleicher continues: “There isn’t a day when we don’t hear our patients say ‘doctor, I wish I’d known about your center years ago, when I was doing such and such…’ The earlier we can start treatment, the better, of course, our chances of helping our patients! This is why we are issuing this fertility tip sheet.”
CHR’s fertility tips for women trying to get pregnant after 40 include:
Recognize the urgency of aggressive fertility treatment when you are above age 40.
Insist on rapid diagnosis and a structured treatment plan.
Insist on specific treatment goals that meet your expectations. For example, do not agree to treatment with clomiphene citrate and intrauterine insemination (IUI) if the expected pregnancy chance sounds ridiculously low.
Do not agree to endless testing to “wait for the right results” – time is not on your side, and results will only get worse!
It never hurts to get a second opinion.
About Center for Human Reproduction
Center for Human Reproduction, or CHR (http://www.centerforhumanreprod.com), is a leading fertility center in the United States with a worldwide reputation as a “fertility center of last resort,” specializing in treatment of infertility in women with diminished ovarian reserve, including younger women with premature ovarian aging (POA) and older women with physiological ovarian aging. Dr. Gleicher is available for additional comments.